An Integrated Approach for Identification of Good Substrates and Optimal Inhibitors

From Apoptosis and Cell Death Research, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA; Division of Medicinal Chemistry and Microbiology, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland; 3 Department of Pathology, Stanford School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Department of Chemistry, University of California, Berkeley, California 94720, USA Running title: Substrate specificity of aminopeptidases Address correspondence to: Marcin Drag, Ph.D., Guy Salvesen, Ph.D., Apoptosis and Cell Death Research, The Burnham Institute for Medical Research, La Jolla, CA 92037, USA; Tel.: 858646-3100; E-mail: [email protected], [email protected]